INFORMATION_SCHEMA provides access to database metadata.
Metadata is data about the data, such as the name of a database or table, the data type of a column, or access privileges. Other terms that sometimes are used for this information are data dictionary and system catalog.
INFORMATION_SCHEMA is the information database, the place that stores information about all the other databases that the MySQL server maintains. Inside INFORMATION_SCHEMA there are several read-only tables. They are actually views, not base tables, so there are no files associated with them.
Therefore, you can safely ignore these tables. They are read-only so they can't be edited or removed.